EMBO fellowship for Doris

Congratulation to Doris for receiving a long-term EMBO fellowship! Let the Chemical Biology begin and all the very best for your Postdoc stay in Craig Crews' lab in Yale. more »

2014 Lab Retreat in Hamburg

Is there any better and inspiring place than DESY for having a lab retreat? Definitely, not. Enjoying the fresh air and the harbor atmosphere in the world's best city, we had a great time at the synchrotron. An unforgettable highlight, in addition to the excellent seminars, was a Tour through the XFEL tunnel and construction site. Really curious when we will use the 3.4 km xray laser for our first next-generation experiment. more »

Fishing the pArg salmon in the shark tank

Arginine phosphorylation is an emerging post-translational protein modification, however its overall prevalence could not been studied by mass spectrometry. One major complication is the great abundance of serine/threonine phosphorylations that outcompetes phosphoarginine by several orders of magnitude. We thus developed a “trapping mutant” of the YwlE arginine phosphatase that can bind pArg proteins but not transform them. Indeed, the YwlE trap allows the selective enrichment of pArg proteins in the cellular pool dominated by O-phosphorylations, as is now published in the journal of Molecular & Cellular Proteomics. more »

PhD defense of Debora

Summa congrats for an excellent thesis and exam. Combining mass spec and protein biochemistry at its best. Great work! more »

2014 Spring Lab Retreat

We did it again, an excursion to the Zotter chocolate manufacture. After in-house validation of our projects, we celebrated the 6-month plan with a chocolate firework at Zotter. Some of the extra kcal's were afterwards burned on the climb to the Riegersburg - an exercise that stimulated further (molecular) machine discussions. more »