pArg study published in Nature as article

2016-10-07

Cells never forget to take out the trash. For this purpose, they label things that need to be discarded. In our latest study, we show that bacteria utilize a specific phospho signal to label damaged proteins that need to be removed.

It has long been known that cells tag proteins for degradation by labelling them with ubiquitin, a signal described as “the molecular kiss of death”. Our group now report an analogous system in gram-positive bacteria, where the role of a degradation tag is fulfilled by a little known post-translational modification: arginine phosphorylation. The discovery opens new avenues for designing antibacterial therapies.

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