pArg study published in Nature as article
Cells never forget to take out the trash. For this purpose, they label things that need to be discarded. In our latest study, we show that bacteria utilize a specific phospho signal to label damaged proteins that need to be removed.
It has long been known that cells tag proteins for degradation by labelling them with ubiquitin, a signal described as “the molecular kiss of death”. Our group now report an analogous system in gram-positive bacteria, where the role of a degradation tag is fulfilled by a little known post-translational modification: arginine phosphorylation. The discovery opens new avenues for designing antibacterial therapies.