VBC Ub Symposium


Every year, a special effort is made to invite known experts in the ubiquitin field. This year, the VBC Ub-Club was happy to welcome two highly distinguished guest speakers, Ami Navon from the Weizmann Institute in Israel and Rachel Klevit from the University of Washington.

Ami Navon expertly talked about his lab’s journey to navigate “The regulatory loops within the proteasome ad their structural bases”. Rachel Klevit passionately told us about her latest insights into BRCA1, a RING E3 ligase known to be mutated in cancer and explained to us the “Rules of the game: The last guy holding the Ubiquitin calls the shots”. In addition to this, a last-minute guest speaker was added to the schedule just two days before the event, David Haselbach from the Max Planck Institute in G?ttingen, who presented beautiful structures of proteasome particles in action, as solved by the continually evolving techniques in cryo-electron microscopy.

The event took place at the Josephinum, a former medical academy founded in 1784 by Emperor Joseph II, in a room decorated with glass cases of leather-bound books on the study of medicine. Approximately 35 people attended, making it a relaxed and comfortable event and not a bad way to spend a Saturday. Attendees ranged from Masters students, PhD students, Post-docs to admired experts in the field. The symposium, like the Ubiquitin club, covered a broad range of topics, ranging from ubiquitin, ubiquitin-like molecules, signaling, autophagy, post-translational modifications, to forms of targeted degradation not mediated by ubiquitination. In the words of one of the distinguished guest speakers, Rachel Klevit: “Everyone works on ubiquitination and if you think that you don’t, you just don’t know it yet.”