Andrzej

PhD student

  • Curriculum Vitae

    * from Oct 2013: PhD student in the Clausen lab

    * 2013 Research internship (2 months), Ludwig-Maximilian’s University of Munich, Biocenter (Prof. Dr. Kirsten Jung). Experimental focus on protein purification, microbiology of halophiles (Vibrio harveyi) and development of high throughput screening assays.

    * 2013 Master thesis, University of Chicago, Department of Biochemistry and Molecular Biology (Dr. D. Allan Drummond). Thesis: “Reducing aggregation of therapeutically relevant proteins”. Experimental focus on protein purification, tandem mass spectrometry and design of protein aggregation assays.

    * 2011-2013 Diploma in Biochemistry, University of Gdansk, Department of Molecular and Cellular Biology (Prof. Dr. Krzysztof Liberek, Dr. Szymon Zietkiewicz).

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Current research interest

The myosin superfamily has been studied for decades already, however many questions regarding this intricate molecular machinery are still left unanswered. For instance, how exactly is myosin folded in cells? What different factors participate in this process? What is the role of general molecular chaperones Hsp70 and Hsp90, and myosin-specific chaperone UNC-45 in folding of myosin? How well is the pathway conserved in organisms harboring muscle sarcomeric structures?

I am primarily interested in the concerted action of molecular chaperones in myosin folding, maintenance and rescue from hazardous conditions jeopardizing the native structure of myosin, such as heat shock. I believe each of those situations elicits the involvement of different protein factors and varying role of the molecular chaperone central to myosin folding – UNC-45.