Abbas

Postdoc

  • Curriculum Vitae

    *Since 2017 Postdoc in Tim Clausen’s group, Institute of Molecular Pathology (IMP), Vienna. Research interest: Structural biology of phosphoarginine interacting proteins.

    *2012-2016 PhD in Prof. Matthias Bochtler’s group, International Institute of Molecular and Cell Biology, Warsaw. Thesis Title: Biochemical and structural studies of 5hmC-Specific endonuclease. 

    *2009-2011 Junior researcher at Indian Institute of Science, Bangalore. Project: Structural biology of Non structural protein 3A in Echovirus.

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Current research interest

The presence and biological importance of the protein modification phosphoarginine (pArg) in Grampositive bacteria has been discovered in our lab. The pArg-labelling of misfolded proteins triggers their degradation via ClpCP system. The same modification on the transcription factor CtsR, regulator of ClpC operon, uncouples its binding to the promoter. Being such a novel and interesting modification, I am interested in the structural biology of the proteins which interact with the pArg tag. Especially, I would like to address the molecular mechanism of how ClpC recognizes and unfolds pArg-marked proteins. To address this question, I use biophysical and structural methods like x-ray crystallography and cryoEM.

Honors and Awards

* 'Best student presentation Prize by International Union of Crystallography' in the Conference, Heart Of Europe Bio crystallography Meeting (HEC-17) held in Berlin, Germany during 25-27 September 2014.

* Outstanding poster presentation award at EMBO young scientist forum, 2-3 July 2015 Warsaw, Poland.

* I belong to the runner up team in the dragon boat race conducted at HEC-17. Hopefully, will be a winner at IMP.

Publications

Asgar Abbas Kazrani, Monika Kowalska, Honorata czapinska and Matthias Bochtler (2014): Crystal Structure Of 5hmC specific Restriction endonuclease PvuRts1I. Nucleic Acid Research ;42(9):5929-36.