Tim

Group Leader

  • Curriculum Vitae

    * 2009 Senior Scientist, Institute for Molecular Pathology (IMP) in Vienna. Research interest: Molecular mechanisms of protein quality control and stress response.

    * 2002 Group Leader in Structural Biology, Institute for Molecular Pathology (IMP) in Vienna. Research interest: Molecular mechanisms of protein quality control and stress response.

    * 1999 Habilitation, University of Konstanz. Thesis on “Analysis of structure-function relationships of pyridoxal 5’-phosphate dependent enzymes”. Venia Legendi in Biochemistry.

    * 1997 PhD thesis, Max-Planck-Institute of Biochemistry, Martinsried, Dept. of Structural Biology (Prof. Dr. Robert Huber). PhD in Chemistry with Summa cum Laude. Thesis on “X-ray structure analysis of different pyridoxal 5’-phosphate-dependent enzymes: Cystathionine beta-lyase, cystathionine gamma-synthase and MalY”. Experimental focus on biophysics, protein chemistry and protein crystallography.

    * 1994 Master thesis, University of Konstanz, Department of Bioorganic Chemistry (Prof. Dr. Sandro Ghisla). Diploma thesis: “Functional analysis of the active site of glycolate oxidase”. Experimental focus on protein purification, enzyme kinetics, stopped-flow technique and development of software for rapid reaction analysis.

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Current research interest

I am particularly interested in the moonlighting function of enzymes. For example, how can the dual functionalities of a protease and a chaperone be combined in a single protein complex and what makes a protein behaving well under condition-1, while running amok under condition-2. Given this Jekyll-Hyde analogy, is there a molecular foundation that can explain the switch towards pathological behavior? So, how can we capture proteins in distinct states and monitor their physical and mechanistic properties? Apparently, such monitoring job requires sophisticated methods, as we currently apply at the Center of Structural Investigation C.S.I. Vienna. In addition, we are interested in understanding the temporary and spatially interplay of the involved players aiming for a 4D understanding of protein quality control.
 

Honors and Awards

* 2010 EMBO member

* 2005 EMBO Young Investigator

* 2004 Heinz Mayer-Leibnitz Prize of the “Deutsche Forschungsgemeinschaft”

* 1994-1997 Max-Planck fellow