a great collaboration with the Koehler group

2015-08-27

... resulted in this great CELL publication.

Congratulation to Doris for her co-first contribution to the CELL paper from the Koehler lab (MFPL). In a very successful collaboration, Doris revealed the crystal structure of the yeast Sac3(222-572) - Thp1(170-455) - Sem1 complex, a structure that guided follow-up biochemical experiments. Together, the in vitro and in vivo findings deciphered a fundamentally important mechanism how nuclear pores employ specific „interpreters“ to modulate gene expression. (abstract)